Biology Activities and Worksheets for High School
High school biology covers topics like cell structure, photosynthesis, genetics, evolution, ecosystems, and human impact on the environment. Students learn how living things function, grow, and interact with each other and their surroundings, following the Next Generation Science Standards.
Here you can find a variety of biology activities and worksheets to use in your classroom or for homework. Materials include interactive quizzes, printable worksheets, and editable resources you can adapt for your students. Assign them online with a class code or print for in-person lessons.
By material type
Materials (24 materials)
Worksheet
DNA structure and replication
This 9th-grade classroom material helps students understand DNA structure and replication through diagram labeling, matching exercises, and sequencing steps, focusing on nucleotides, base pairing, the double helix, and semi-conservative replication.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Mutations practice
This resource helps 11th-grade students practice identifying different types of mutations, including point mutations and frameshift mutations, through question sequences such as multiple-choice, sequencing, and matching exercises that analyze their effects using a codon chart.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Protein synthesis practice
This 10th-grade protein synthesis practice activity helps students reinforce their understanding of transcription and translation by answering questions on mRNA, codons, and amino acids. Students identify key molecules, sequence steps, and match terms to descriptions through various question types.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Climate change and carbon footprint practice
This classroom material helps 11th-grade students practice understanding climate change topics through varied question types, including multiple-choice, ordering, and fill-in-the-blank questions. Students analyze greenhouse effect concepts, identify carbon sinks, interpret CO2 data, and explore ways to reduce their carbon footprint.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Human impact on ecosystems
This 10th-grade lesson engages students in analyzing human impacts on ecosystems through multiple question types, including multiple choice, select-all, sequencing, and fill-in-the-blank exercises. The focus is on understanding cause-and-effect relationships related to deforestation, invasive species, habitat fragmentation, and overfishing.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Types of pollution practice
This 9th-grade lesson offers practice in identifying types of pollution by answering multiple-choice, multiple-answer, ordering, and matching questions. Students explore sources, effects, and solutions related to air, water, soil, noise, and light pollution through interactive activities.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Photosynthesis and respiration compared
A worksheet for 11th-grade students practicing comparing photosynthesis and respiration through multiple-choice and short-answer questions focusing on equations, organelles, energy transfer, and their roles in carbon and oxygen cycling.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Cellular respiration practice
This 10th grade practice material helps students understand cellular respiration by asking questions about glycolysis, Krebs cycle, electron transport chain, ATP production, and differences between aerobic and anaerobic processes. Students organize stages, identify products, and complete key concepts through varied question types.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Photosynthesis equation and steps
This classroom material helps 9th-grade students understand the photosynthesis process by practicing questions on reactants, products, chloroplast structures, and the steps involved, including light-dependent reactions and the Calvin cycle, through multiple-choice and matching activities.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Plant and animal cells compared
A comparative exercise where students identify and differentiate plant and animal cell structures, such as the cell wall and chloroplasts, through multiple-choice and matching questions; also includes ordering and classification tasks aimed at 10th-grade learners.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Cell organelles and their functions
This 9th grade classroom material helps students practice matching cell organelles like the nucleus, mitochondria, ribosomes, endoplasmic reticulum, Golgi apparatus, lysosomes, chloroplasts, and cell membrane to their functions. It includes questions on energy production, genetic material, protein synthesis, and organizing steps of protein transport.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Cell membrane and transport practice
An 11th-grade cellular biology practice focusing on the cell membrane and transport processes, where students answer various questions on the phospholipid bilayer, diffusion, osmosis, facilitated diffusion, active transport, and solution-term identification, to reinforce understanding of membrane functions and movement mechanisms.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Natural selection practice
This 9th-grade classroom resource enables students to practice understanding natural selection by answering multiple-choice and sequencing questions focused on variation, overproduction, competition, survival, and reproduction, using real-world examples like peppered moths and antibiotic resistance. Students organize concepts, identify necessary conditions, and apply the steps of natural selection through structured questions.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Types of natural selection and speciation
This 11th-grade material explores the different types of natural selection—stabilizing, directional, and disruptive—and concepts of speciation, including geographic and reproductive isolation. Students practice identifying selection types, distinguishing isolation mechanisms, ordering allopatric speciation steps, and completing sentences about trait shifts.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Evidence for evolution practice
This material offers 10th-grade students practice with evidence for evolution through questions on vestigial organs, fossil formation steps, and matching structures to their types. Students engage with multiple-choice, sequencing, and matching exercises to reinforce understanding of fossils, homologous and analogous structures, embryology, and DNA comparisons.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Biodiversity and its importance
This educational material helps 9th-grade students practice understanding biodiversity by answering multiple-choice questions on genetic, species, and ecosystem diversity, ecosystem services, and human-induced threats, encouraging comprehension of ecological concepts and current environmental issues.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Ecological succession practice
This 11th-grade activity helps students understand ecological succession by identifying differences between primary and secondary succession, recognizing pioneer species, and sequencing stages, through multiple-choice and ordering questions based on real-world examples like fires and volcanoes.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Population growth and carrying capacity
This 10th-grade classroom material helps students understand population dynamics by analyzing graphs of exponential versus logistic growth, identifying factors that limit population size, and sequencing phases of logistic growth through guided questions and practical exercises.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
How body systems work together
This classroom material guides 11th-grade students through how body systems interact during exercise, using case scenarios, matching exercises, and sequencing questions to understand responses like respiratory and circulatory collaboration, homeostasis maintenance, and reaction to increased carbon dioxide.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Non-Mendelian inheritance practice
This 11th-grade classroom material provides practice in non-Mendelian inheritance through a series of questions and exercises on incomplete dominance, codominance, multiple alleles, blood types, and sex-linked traits using Punnett squares. Students identify key concepts, analyze statements, and apply their understanding by matching inheritance patterns to examples.
Biology · Grade 11 · New · Oct 15, 2026
Worksheet
Monohybrid Punnett squares practice
A classroom resource for 9th-grade students to practice monohybrid Punnett squares, focusing on dominant and recessive alleles, genotype and phenotype, and homozygous and heterozygous traits. Students determine expected ratios, identify homozygous genotypes, and fill in missing key terms through guided questions.
Biology · Grade 9 · New · Oct 15, 2026
Worksheet
Dihybrid cross practice
This classroom material offers 10th-grade students practice with dihybrid crosses, focusing on two-trait inheritance, gamete formation using FOIL, and calculating phenotypic ratios like 9:3:3:1 through independent assortment. Activities include identifying gametes, sequencing FOIL steps, and solving probability problems.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Human body systems and their functions
This 10th-grade classroom material helps students match human body systems like circulatory, respiratory, digestive, nervous, endocrine, immune, excretory, muscular, and skeletal to their organs and functions. It includes questions on identifying key organs, ordering digestive steps, and matching systems to their roles.
Biology · Grade 10 · New · Oct 15, 2026
Worksheet
Homeostasis and feedback loops practice
This 9th-grade material helps students practice understanding homeostasis and feedback loops through multiple-choice questions, fill-in-the-blank exercises, and ordering steps. It focuses on negative and positive feedback related to body temperature and blood glucose regulation.
Biology · Grade 9 · New · Oct 15, 2026
Topics
- Punnett Square Worksheets for Inheritance and Variation (Grades 9–12)
- Protein Synthesis Worksheets for High School Biology
- Photosynthesis Worksheets for High School Biology
- Mitosis Worksheets and Meiosis Resources for High School Biology
- Body Systems Worksheets: Homeostasis and Body Systems (Grades 9–12)
- Cell Structure and Function Worksheets for High School Biology
- Evolution Worksheets for High School Biology: Natural Selection
- Biodiversity Worksheets for High School Ecosystems and Populations
- Pollution Worksheets for Human Impacts on the Environment (Grades 9–12)
Questions teachers ask
What topics do these biology worksheets cover?
The worksheets cover core high school biology topics such as cell structure, genetics, evolution, ecosystems, and human impact on the environment.
Can I edit and customize the biology activities?
Yes, you can copy any worksheet or activity, modify it to fit your class needs, and create your own using AI tools.
How can I assign these materials to my students?
You can assign materials online by sharing a class code or print them for use in the classroom or as homework.